RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
AK081284
RNA ID
RNA Type
lncrna
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
RT-PCR
Target
NA
Pathway
NA
PubMed ID
Title
Ablation of interleukin-17 alleviated cardiac interstitial fibrosis and improved cardiac function via inhibiting long non-coding RNA-AK081284 in diabetic mice
Year
2018
Function
"The levels of long noncoding RNA-AK081284 were increased in the cardiac fibroblasts (CFs) treated with high glucose or interleukin-17(IL-17). Knockout of IL-17 abrogated high glucose induced upregulation of AK081284. Overexpression of AK081284 in cultured CFs promoted the production of collagen and TGF-beta1. Both high glucose and IL-17 induced collagen and TGF-beta1 production were mitigated by the application of the siRNA for AK081284. In summary, deletion of IL-17 is able to mitigate myocardial fibrosis and improve cardiac function of diabetic mice. The IL-17/AK081284/TGFbeta1 signaling pathway mediates high glucose induced collagen production."